Hiroe HARA / D3
  • TEL：
HiroeHara

Research topic

Development of a novel method for the assessment of recycled water safety using toxicogenomic approach

Research abstract

A variety of chemicals discharged from our daily life and industrial activities are expected to remain in the reclaimed water. Conventional evaluation methods based on the toxicity of each component are now facing difficulties to examine the combined effects of numerous micropollutants and their degradation products. In this study, toxicogenomic approach is employed to collect the basic information for developing a novel assessment method of combined toxic effects of reclaimed water.

Papers
  1. Evaluation of whole wastewater effluent impacts on HepG2 using DNA microarray-based transcriptome analysis
    Hara-Yamamura, H., Nakashima, K., Hoque, A., Miyoshi, T., Kimura, K., Watanabe, Y. and Okabe, S.
    Environmental Science and Technology, 2013, 47(10), 5425-5432.
  2. Elimination of selected pharmaceuticals by biosolids from municipal wastewater treatment plants: importance of modest pH change and degree of mineralization
    Kimura, K., Hara, H., and Watanabe, Y.
    Water Science and Technology, 2010, 65(2), 1084-1089.
  3. Elimination of selected acidic pharmaceuticals from municipal wastewater by an activated sludge system and membrane bioreactors
    Kimura, K., Hara, H., and Watanabe, Y.
    Environmental Science and Technology, 2007, 41(10), 3708-3714.
  4. Removal of pharmaceutical compounds by submerged membrane bioreactors (MBRs)
    Kimura, K., Hara, H., and Watanabe, Y.
    Desalination, 2005, 178(1-3), 135-140.
International conference proceedings
  1. Searching for biologically active fraction of wastewater effluents using toxicogenomic approach
    Hiroe Hara-Yamamura
    2nd International Doctraol Symposium with Partner Universities.
    Hokkaido University, Sapporo, Japan.
    Oct. 24-25th, 2013
  2. Toxicity assessment of tertiary treated municipal wastewater by toxicogenomic approach
    Hara-Yamamura, H., and Okabe, S.
    The 4th IWA-ASPIRE.
    International Conference on Environmental OMICS, Guangzhou, P. R. China.
    Nov. 8-12, 2011.
  3. Evaluating short-term and long-term effect of arsenic exposure on human hepatoma cells
    Hara-Yamamura, H., Taga, T., Kawata, K., and Okabe, S.
    The 4th IWA-ASPIRE.
    Tokyo, Japan.
    Oct. 2-6, 2011.
  4. Toxicity assessment of tertiary treated municipal wastewater by toxicogenomic approach
    Hara, H., and Okabe, S.
    The 15th International Symposium on Toxicity Assessment.
    Hong Kong, P. R. China.
    Jul. 3-8, 2011.
  5. The Removal of Pharmaceutical Residues by Membrane Bioreactors
    Hara, H., Kimura, K., and Watanabe, Y.
    The 3rd COE Workshop of MBR
    Sapporo, Japan.
    Jun. 11, 2005.