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Laboratory of Applied BioChemistry
Division of Applied Chemistry
Faculty of Engineering / Graduate School of Chemical Sciences and Engineering,
Hokkaido University
What's new
- 2024/4/1
One grad and four undergrads joined the group.
- 2024/3/26
We had Dairi's group reunion at Tokyo.
- 2024/3/25
Ning Shen obtained her Ph.D degree. Congratulations!
- 2024/1/11
New publication in Journal of Antibiotics!
Umetsu et al. "Identification of a new oligomycin derivative as a specific inhibitor of the alternative peptidoglycan biosynthetic pathway"
link
- 2023/12/28
New publication in Journal of Bioscience and Bioengineering!
Shen et al. "Optimization of tyrosol-producing pathway with tyrosine decarboxylase and tyramine oxidase in high-tyrosine-producing Escherichia coli"
link
- 2023/12/15
New publication in Biomacromolecules!
Kato and Sakuta et al. "Peptide Epimerase Responsible for D-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis"
link
- 2023/9/25
Wanlu Xiao obtained her Ph.D degree. Congratulations!
- 2023/8/8
Collaborative work with Prof. Morita (University of Toyama) has been published in Nature Communications!
"Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism"
Link
- 2023/8/8
New publication in Bioscience, Biotechnology, and Biochemistry!
Xiao et al. "Peptide epimerase-dehydratase complex responsible for biosynthesis of the linaridin class ribosomal peptides"
link
- 2023/5/26
JSBBA Award Review by Prof. Dairi was published in Bioscience, Biotechnology, and Biochemistry.
Link
- 2023/5/17
Collaborative work with Prof. Tsung-Lin Li (Academia Sinica, Taiwan) and Prof. Yoshimitsu Hamano (Fukui Prefectural University) has been published in Nature Communications!
"N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry"
Link
- 2023/4/3
One grad and four undergrads joined the group.
- 2023/3/17
Professor Dairi received JSBBA Award (Awarded to members with honorable research achievements in the fields of Bioscience, Biotechnology, and Agrochemistry). Congratulations!
- 2022/11/7
Collaborative work with Assoc. Prof. Hirasawa (Tokyo Institute of Technology) has been published in Journal of Bioscience and Bioengineering!
"Ergothioneine production by Corynebacterium glutamicum harboring heterologous biosynthesis pathways"
Link
- 2022/10/27
Collaborative work with Prof. Hamano (Fukui Prefectural University) has been published in Communications Biology!
"First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria"
Link
- 2022/10/3
A research assistant professor Takeshi Tsunoda joins the group.
- 2022/9/30
Our ChemBioChem research article "Biosynthetic Gene Cluster of linaridin Peptides Contains Epimerase Gene" was highlighted in Breakthrough Technologies of MEDICINE INNOVATES
Link
- 2022/6/13
A research student Zhang, Guoxin joins the group.
- 2022/4/23
New publication in ChemBioChem!
Xiao et al. "Biosynthetic Gene Cluster of linaridin Peptides Contains Epimerase Gene"
link
- 2022/4/1
Our presentation was selected as Hot Topics Award at 2022 Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry!
Riku Nakama, Hiyu Kobayashi, Makoto Otsuka, Yasuharu Satoh, Yasushi Ogasawara, and Tohru Dairi
Dissecting Biosynthetic Machinery of Microalgal Polyunsaturated Fatty Acid Synthase.
Online, March 15-18, 2022
- 2022/4/1
Two grads and four undergrads joined the group.
- 2021/12/14
New publication in Angewandte Chemie International Edition!
Li et al. "Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes"
link
- 2021/8/21
New publication in Journal of Antibiotics!
Ogasawara et al."Identification of pulvomycin as an inhibitor of the futalosine pathway"
link
- 2021/6/12
Mini review published in Journal of Industrial Microbiology and Biotechnology!
Ogasawara et al."Discovery of an alternative pathway of peptidoglycan biosynthesis: A new target for pathway specific inhibitors"
link
- 2021/4/1
Three grads and five undergrads joined the group.
- 2021/3/25
Zhi Feng obtained his Ph.D degree. Congratulations!
- 2021/1/15
Collaborative work with Prof. Morita (University of Toyama) has been published in Bioorganic & Medicinal Chemistry Letters!
Link
- 2020/12/29
New publication in Chemical Science!
Feng et al."Identification of the Peptide Epimerase MslH Responsible for D-amino Acid Introduction at the C-terminus of Ribosomal Peptides"
link
- 2020/12/16
Zhi Feng (D3) received a best presentation award in Hokkaido branch symposium, Japan Society for Bioscience, Biotechnology, and Agrochemistry. The presentation title is "Identification and Characterization of the Peptide Epimerase Catalyzing Isomerization of the C-terminal L-Tryptophan Residue in the Biosynthesis of Lasso Peptide, MS-271". Congratulations!
- 2020/10/1
Ning Shen earned her Master’s Degree and joined the Ph.D Program.
- 2020/5/21
New publication in Journal of Agricultural and Food Chemistry!
Kamide et al."High production of ergothioneine in Escherichia coli using the sulfoxide synthase from Methylobacterium strains"
link
- 2020/5/19
New publication in Current Opinion in Chemical Biology!
Hayashi et al."Recent advances in functional analysis of polyunsaturated fatty acid synthases"
link
- 2020/4/1
Four undergrads join the group.
- 2020/3/25
Shohei Hayashi obtained his Ph.D degree. Congratulations!
- 2020/02/28
New publication in ACS Chemical Biology!
Hayashi et al."Off-loading Mechanism of Products in Polyunsaturated Fatty Acid Synthases"
link
- 2019/11/15
New publication in ACS Chemical Biology!
Naka et al."Subtle control of carbon chain length in polyunsaturated fatty acid synthases"
link
- 2019/10/25
New publication in Journal of Antibiotics!
Ogasawara et al."Identification of actinomycin D as a specific inhibitor of the alternative pathway of peptidoglycan biosynthesis"
link
- 2019/9/25
Ruoyin Feng obtained her Ph.D degree. Congratulations!
- 2019/7/29
Makoto Ohtsuka (M1) received a poster award in International Symposium on Biopolymer Synthesis and Degradation (7/29-30) held in Hokkaido University. The poster title is "Engineering of polyunsaturated fatty acid synthase to alter the product specificity". Congratulations!
- 2019/7/10
New publication in Bioorganic & Medicinal Chemistry Letters!
Ogasawara et al "In vitro characterization of MitE and MitB: formation of N-acetylglucosaminyl-3-amino-5-hydroxybenzoyl-MmcB as a key intermediate in the biosynthesis of antitumor antibiotic mitomycins"
link
- 2019/7/5
Our research article about MS-271 biosynthesis published in ChemBioChem was selected for Special Collection ChemBioChem Readers' choice 2019!
- 2019/5/16
New publication in Organic Letters!
Ogasawara et al "Involvement of Peptide Epimerization in Poly-γ-glutamic Acid Biosynthesis"
link
- 2019/4/25
Our presentation was selected as Hot Topics Award at 2019 Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry!
Shohei HAYASHI, Yasushi OGASAWARA, Yasuharu SATOH, Chitose MARUYAMA, Yoshimitsu HAMANO, Tetsuro UJIHARA, and Tohru DAIRI
Control mechanism for carbon chain length in polyunsaturated fatty acid synthases.
Tokyo University Of Agriculture, March 24-27, 2019
- 2019/4/18
New publication in ACS Chemical Biology!
Feng et al "Amino Acid Residues Recognizing Isomeric Glutamate Substrates in UDP-N-acetylmuramic acid-L-alanine-glutamate Synthetases"
Link
- 2019/4/1
Five undergrads join the group.
- 2019/3/8
New publication in Angewandte Chemie International Edition!
Hayashi et al "Control mechanism for carbon chain length in polyunsaturated fatty acid synthases"
Link
- 2019/2/14
Collaborative work with Prof. Otsu (University of Tsukuba) has been published in Scientific Reports!
Tanaka et al "Gram-scale fermentative production of ergothioneine driven by overproduction of cysteine in Escherichia coli.
Scientific Reports 9, 1895 (2019)
Link
- 2019/1/9
New publication in Angewandte Chemie International Edition!
Hayashi et al "Control mechanism for cis double bond formation by polyunsaturated fatty acid synthases"
Link
- 2018/12/25
New publication in Bioscience, Biotechnology, and Biochemistry!
"New enzymes for peptide biosynthesis in microorganisms."
Link
- 2018/12/16
Yohei Shimizu (M1) received a student best presentation award in Hokkaido Branches symposium, The Japan Society for Bioscience, Biotechnology, and Agrochemistry (12/15-16). Congratulations!
- 2018/12/2
New publication in Current Opinion in Chemical Biology!
"Novel enzymology in futalosine-dependent menaquinone biosynthesis."
Link
- 2018/11/22
New publication in Journal of Industrial Microbiology & Biotechnology!
Ogasawara et al "Searching for potent and specific antibiotics against pathogenic Helicobacter and Campylobacter strains"
Link
- 2018/11/1
Kenshin Ikeuchi (M1) received a student best presentation award in Hokkaido and Tohoku Branches Joint symposium, The Japan Society for Bioscience, Biotechnology, and Agrochemistry (9/22-23). Congratulations!
- 2018/10/18
New publication in Bioscience, Biotechnology, and Biochemistry!
Takusagawa et al "Ergothioneine production with Aspergillus oryzae"
Link
- 2018/10/5
Shohei Hayashi (D2) received a student poster award in Northern Japan Branch symposium, The Society for Biotechnology, Japan. Congratulations!
- 2018/10/01
First year graduate student Ning Shen joins the group.
- 2018/9/30
The article about MS-271 biosynthesis published in ChemBioChem was selected for front cover image of 2018 Volume 19, Issue 19!
- 2018/8/9
New publication in Journal of Antibiotics!
Shimizu et al "Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway"
Link
- 2018/7/6
New publication in ChemBioChem!
Feng et al "Biosynthetic Gene Cluster of a D‐Tryptophan‐Containing Lasso Peptide, MS‐271"
Link
- 2018/4/1
Four undergrads join the group.
First year graduate student joins the group.
Zhi Feng earned his Master’s Degree and joined the Ph.D Program.
